AmpG

__**AmpG: The Key Permease Involved in Peptidoglycan Recycling**__

AmpG is the key permease involved in the recycling of peptidoglycan. It belongs to the major facilitator superfamily, and is interesting in that it is able to transport relatively large molecules (MW 992). It is a membrane protein with 10 transmembrane segments and four other hydrophobic segments that remain in the cytoplasm.

AmpG is the permease involved in the transport of anh-muropeptides. It is specific for the free GlcNAc-anhMurNAc disaccharide and disaccharide carrying stem peptides, and requires the proton motive force. It does not transport the anhMurNAc-tripeptide.

The //ampG// gene and //yajG// gene (coded upstream of //ampG//) form an operon. However, it has been shown that //yajG//, a putative lipoprotein, is not involved in either beta-lactamase induction or the expression of AmpG.