Mpl

= __**Mpl: UDP-//N//-Acetylmuramate to L-Alanyl-y-D-Glutamyl-//meso//-Diaminopimelate Ligase**__ = = = __**Gene Names:**__ __**Function:**__ Mpl (murein peptide ligase) allows for the direct utilisation of the murein tripeptide (L-Ala-y-D-Glu-meso-Dap) without first breaking it down into individual amino acids (Park and Uehara, 2008). It has recently been shown to utilise the tripeptide, tetrapeptide and pentapeptide with similar efficiencies, but only accepts the dipeptide or L-Ala very poorly (Herve et al, 2007).
 * yifG
 * mpl

In addition, it can accept peptides containing lysine instead of meso-diaminopimelic acid (Dap), but this substitution causes a significant decrease in catalytic efficiency (Herve et al, 2007). This is of relevance, since L-Lys is often present, instead of Dap, in Gram positive bacteria (Winn et al, 2010).

__**Regulation:**__ During stationary phase, the expression level of Mpl increases under the control of Sigma S (Park and Uehara, 2008).

__**Mutations:**__ Cells containing mutated mpl genes were shown to have a normal morphology and peptidoglycan content, but to contain a 12-fold-higher pool of tripeptide in their cytoplasm than wild type cells (Park and Uehara, 2008).


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