UppS

=UppS=

__**Function:**__ UppS (undecaprenyl pyrophosphate synthase) catalyses the consecutive addition of eight isopentyl units onto farnesyl pyrophosphate. UppS belongs to the cis-prenyltransferases group IV (Bouhss et al, 2008).

__**Location:**__ UppS is a soluble, cytoplasmic enzyme, that generates a membrane embedded product, similar to the enzymes involved in fatty acid synthesis (Bouhss et al, 2008).

Upps shows both a detergent and Magnesium Chloride dependency.
 * __Mechanism:__**

__**Structure:**__ The crystal structure of UppS from E. coli has been characterised in great detail, both in apo form and in complex with Magnesium, isopentenyl phosphate, FPP and product analogues (see links below).
 * Structure of E. coli Undecaprenyl Pyrophosphate Synthase (2001)
 * Crystal Structure of Undecaprenyl Pyrophosphate Synthase in Complex with Mg, IPP and Fspp